Navalny was poisoned with exotic frog toxin, five Western nations confirm

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Five European countries have confirmed that Navalny was poisoned with epibatidine — a high-potency neurotoxin derived from South American poison dart frogs. Traces of the toxin were found in tissue samples covertly taken from Alexei Navalny’s body and smuggled out of Russia. Chemical weapons specialists say the toxin’s effects match Navalny’s reported symptoms before death.

Two years ago, Russian opposition leader and outspoken Putin critic Alexei Navalny died in a penal colony above the Arctic Circle. He was 47. Russian investigators attributed his death to a “combination of illnesses.” From the very beginning, that official announcement drew public skepticism and even ridicule. Now those doubts have been definitively confirmed. According to information obtained by The Insider and Der Spiegel, laboratories in Western countries — and validated by the United Kingdom, France, Germany, Sweden, and the Netherlands — have independently analyzed biological samples taken from Navalny’s body and reached the same conclusion: the samples contain epibatidine, a highly toxic alkaloid extracted from the skin of the South American phantasmal poison frog (Epipedobates tricolor). The samples were covertly obtained by Navalny’s family after his death and smuggled out of Russia to the West.

The five nations plan to release a joint statement today on the sidelines of the Munich Security Conference declaring that Navalny was, with a high degree of certainty, poisoned. They also intend to submit their findings to the Organisation for the Prohibition of Chemical Weapons (OPCW), accusing Russia of failing to destroy its chemical weapons stockpile in violation of its treaty obligations.

A neurotoxin that causes paralysis, then death

Epibatidine is a chlorinated alkaloid first discovered by American chemist John Daly in 1974, though its molecular structure was not fully determined until 1992. It is a potent neurotoxin that acts on both nicotinic and muscarinic acetylcholine receptors — the receptors responsible for transmitting pain signals and controlling movement throughout the central and peripheral nervous system. The toxin causes progressive full-body numbness that can rapidly advance to total paralysis.

Death occurs when the paralysis triggers respiratory failure. In vitro studies indicate that epibatidine is barely metabolized in the human body, and its peak concentration in the brain is reached approximately 30 minutes after ingestion.

At higher doses, the progression is stark: paralysis, loss of consciousness, seizures, coma, and death. The substance initially attracted interest as a potential non-opioid painkiller, since it is roughly 200 times more potent than morphine as an analgesic. But researchers quickly discovered that the toxic dose was far too close to the therapeutic dose to be safe for clinical use.

“The symptoms are textbook”

Two chemical weapons specialists consulted by The Insider, both speaking on condition of anonymity due to the sensitivity of the matter, said the known details of Navalny’s final hours are consistent with epibatidine poisoning.

“What we know about Navalny’s condition before death — the sudden collapse, the loss of consciousness, the failure to resuscitate — aligns precisely with what you would expect from a fast-acting nicotinic receptor agonist like epibatidine,” said one specialist, a toxicologist with experience advising Western governments on chemical weapons defense. “The symptoms are textbook. The body simply shuts down.”

A toxin that cannot be acquired by chance

The choice of epibatidine as a weapon, if confirmed, would represent a significant departure from previous Kremlin-linked poisonings. Unlike Novichok — the Soviet-developed nerve agent used in the 2018 Salisbury attack on double agent Sergei Skripal and in the 2020 attempt on Navalny himself — epibatidine is a naturally occurring compound. But obtaining it in quantities sufficient for assassination is far from straightforward.

The phantasmal poison frog, the species that produces epibatidine, was designated a protected species in 1984. Crucially, frogs raised in captivity do not produce the toxin — they do not synthesize epibatidine themselves but accumulate it from their diet of beetles, ants, mites, and flies in the wild. The first chemical synthesis of epibatidine was achieved in 1993, and producing it requires sophisticated laboratory capability.

“This is not something you order online,” the first specialist told The Insider. “You would need a state-level chemical program or access to an advanced research laboratory. The number of actors capable of synthesizing and weaponizing epibatidine is extremely small.”

A pattern of chemical assassinations

The finding adds to a growing dossier of chemical attacks attributed to the Russian state. In March 2018, former GRU officer Sergei Skripal and his daughter Yulia were poisoned with Novichok in Salisbury, England. They survived, but Dawn Sturgess, a 44-year-old British woman, later died after coming into contact with a discarded perfume bottle that had been used to transport the nerve agent.

In August 2020, the FSB used Novichok in an assassination attempt against Navalny. He fell gravely ill on a flight from Tomsk to Moscow and was eventually evacuated to Berlin’s Charité hospital, where doctors saved his life. The operatives responsible were subsequently identified through a joint investigation by The Insider, Der Spiegel and Bellingcat.

Last year, Navalny’s widow Yulia Navalnaya publicly accused Russia of poisoning her husband, citing “foreign laboratory findings.” At the time, she did not disclose which toxin had been detected, but called for the full test results to be made public. Today’s joint declaration by five Western governments vindicates her claims.

Implications

The planned OPCW referral signals that the five governments view Navalny’s killing not merely as a political assassination but as a violation of the Chemical Weapons Convention. The implicit charge is severe: that Russia, a state party to the Convention, maintains an active and evolving chemical weapons capability that it has deployed repeatedly against individuals on foreign and domestic soil.

The findings confirm the conclusions of The Insider’s 2024 investigation that Alexei Navalny was poisoned in an Arctic penal colony.